Recombinant Human IL-7 Protein (GMP Grade)
Catalog Number： PM109-01
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Product Details
Interleukin-7 (IL-7) is a non-redundant cytokine produced by non-lymphoid cells, and can also be secreted by dendritic cells, macrophages, and fibroblasts. It is essential for T cell development in both humans and mouse, as well as B cell development in mouse [1]. IL-7 delivers growth and survival signals through the IL-7 receptor, helping to maintain the size and subset composition of the peripheral T cell pool. IL-7 regulates memory CD8⁺ T cells in response to viral infections. When combined with adoptive transfer of T cells following herpes simplex virus type I infection, IL-7 can enhance viral clearance [2]. Additionally, IL-7 can improve immune recovery after allogeneic hematopoietic stem cell transplantation without inducing severe toxicity, even in cases of T-cell exhaustion [3].
at -18℃ or below for two years.
Dry ice (-70℃)
[1] Moniuszko M, Fry T, et al. Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo. J Virol. 2004 Sep;78(18):9740-9.
[2] Meyer A, Parmar PJ, Shahrara S. Significance of IL-7 and IL-7R in RA and autoimmunity. Autoimmun Rev. 2022 Jul;21(7):103120.
[3] Kaiser FMP, Janowska I, et al. IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion. Blood. 2023 Sep 28;142(13):1113-1130.
