Product Catalog

Recombinant Human IL-2 Protein (GMP Grade)

Catalog Number: PM101-01

Price:Please inquire first

Specification:
100 μg
1000 μg

Product Details

Interleukin-2 (IL-2), the first cloned interleukin factor, also known as T-cell growth factor (TCGF), binds to the IL-2 receptor (IL-2R) to stimulate T cells into the cell division cycle, enabling long-term T-cell survival in vitro [1]. In addition to its effects on T cells, IL-2 can also bind to IL-2R on the surface of NK cells, enhancing their proliferation and cytotoxic activity [2]. As a pleiotropic cytokine, IL-2 further promotes the proliferation of tumor-infiltrating lymphocytes, induces B-cell proliferation and immunoglobulin production, and enhances macrophage phagocytic activity [3].

This product consists of 134 amino acid residues, expressed in CHO cells, and is lyophilized after isolation and highly purified.


Storage

at -18˚C or below for two years


Shipping

Dry ice (-70℃)

Product Composition


ComponentPM101-01PM101-02
Recombinant Human IL-2 Protein (GMP Grade)1×10^6 IU/100 μg1×10^7 IU/1 mg


References

[1] Malek TR. The Biology of Interleukin-2. Annual Review of Immunology 2008, 26(1):453-479.

[2] Becker PSA, Suck G, Nowakowska P, Ullrich E, Seifried E, Bader P, Tonn T, Seidl C. Selection and expansion of natural killer cells for NK cell-based immunotherapy. Cancer Immunology, Immunotherapy 2016, 65(4):477-484.

[3] Gaffen S, Liu K. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004, 28(3):109-123.


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