Recombinant Human IL-21 Protein (GMP Grade)
Catalog Number： PM111-01
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Product Details
Interleukin-21 (IL-21) is a type I cytokine that shares a high degree of homology with IL-2, IL-4, and IL-15, and it shares the γ c receptor subunit with IL-7 and IL-9 [1-2]. IL-21 is secreted by activated CD4+ T cells, has a molecular structure similar to that of IL-15, and is involved in regulating B cell proliferation. It synergizes with IL-15 to promote the proliferation of bone marrow precursor cells, as well as the proliferation, differentiation, and cytotoxic activity of natural killer (NK) cells [3-5].
Storage
at -20°C for two years.
Shipping
Dry ice (-70℃)
[1] Ma SW, Huang X, Li YY, et al. High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B. J Hepatol. 2012 Apr;56(4):775-81.
[2] Li J, Ren W, Ma W, Zhang J, Shi J, Qin C. Interleukin-21 responses in patients with chronic hepatitis B. J Interferon Cytokine Res. 2015 Feb;35(2):134-42.
[3] Shi Y, Chen Z, Zhao Z, Yu Y, Fan H, Xu X, Bu X, Gu J. IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate- to-Severe Plaque Psoriasis Patients. Front Immunol. 2019 Aug 7;10:1865.
[4] Nalbant A. IL-17, IL-21, and IL-22 Cytokines of T Helper 17 Cells in Cancer. J Interferon Cytokine Res. 2019 Jan;39 (1):56-60.
[5] Sun S, Chen H, Zheng X, Ma C, Yue R. Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation. Exp Ther Med. 2018 Oct;16(4):3395-3398.
