Recombinant Human IL-18 Protein (GMP Grade)
Catalog Number： PM110-01
Price：Please inquire first
Product Details
Interleukin-18 (IL-18), also known as interferon-gamma-inducing factor, is a pro-inflammatory cytokine produced by various cell types, including hematopoietic and non-hematopoietic cells[1]. The primary function of IL-18 is to induce Th1 cells to secrete interferon-gamma (IFN-γ). This cytokine works synergistically with IL-12 to facilitate the differentiation of Th1 cells, which is critical for the host’ s defense mechanisms against intracellular bacteria, viruses, and fungi[2]. The combined action of IL-18 and IL-12 can activate cytotoxic T cells and natural killer cells to produce IFN-γ, potentially contributing to tumor immunity. The biological activity of IL-18 is not limited to these cells; it also plays a role in the development of Th17 cell responses. IL-18, in synergy with IL-23, can induce Th17 cells to secrete IL-17[3].
Storage
at -20°C for two years.
Shipping
Dry ice (-70℃)
[1] Hu B, Ren J, Luo Y, Keith B, Young RM, Scholler J, Zhao Y, June CH. Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18. Cell Rep. 2017, 20(13):3025-3033.
[2] Ihim SA, Abubakar SD, Zian Z, Sasaki T, Saffarioun M, Maleknia S, Azizi G. Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment. Front Immunol. 2022, 13:919973.
[3] Mi J, Liu Z, Pei S, Wu X, Zhao N, Jiang L, Zhang Z, Bai X. Mendelian randomization study for the roles of IL-18 and IL-1 receptor antagonist in the development of inflammatory bowel disease. Int Immunopharmacol. 2022, 110:109020.
