ProteinFind® Anti-Thy-1/CD90 Mouse Monoclonal Antibody
Catalog Number： HS903-01
Price：Please inquire first
Product Details
Thy-1/CD90 is a GPI-anchored, developmentally regulated cell surface glycoprotein. It is involved in cell adhesion and cell communication of many cell types, especially in immune and nervous system cells. Thy-1/CD90 is widely used as a marker for hematopoietic stem cells [1]. Decreased expression of Thy1/CD90 mRNA and protein has been associated with the development of epithelial ovarian cancer, suggesting it may have a potential role of human ovarian cancer tumor suppressor genes [2]. Thy1/CD90 knockout mice have been shown to have impaired skin immune response and abnormal retinal development [3]. Thy1/CD90 is epigenetic regulated or dysregulated in some disease states such as pulmonary fibrosis, and the potentially reversible hypermethylation of the Thy1/CD90 promoter may provide new treatment options for this disease [4].
Storage
at -20℃ for two years.
Shipping
Dry ice (-70℃)
[1] Majeti R, Park CY, Weissman IL. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood [J]. Cell Stem Cell. 2007, 1(6): 635-45.
[2] Abeysinghe HR, Cao Q, Xu J, et al. THY1 expression is associated with tumor suppression of human ovarian cancer [J]. Cancer Genet Cytogenet. 2003, 143(2): 125-32.
[3] Simon PD, Mcconnell J, Zurakowski D, et al. Thy-1 is critical for normal retinal development [J]. Brain Res Dev Brain Res. 1999, 117(2): 219-23.
[4] Sanders YY, Pardo A, Selman M, et al. Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis [J]. Am J Respir Cell Mol Biol. 2008, 39(5): 610-8.
