ProteinFind® Anti-CD45 Mouse Monoclonal Antibody
Catalog Number： HI106-01
Price：Please inquire first
Product Details
CD45 is a single chain type I transmembrane glycoprotein of 180-240 kDa[1], also known as Protein tyrosine phosphatase, receptor type C (PTPRC), or T200 glycoprotein, T200 leukocyte common antigen, etc., are expressed in the plasma membraneof all hematopoietic cells except red blood cells or platelets [2]. CD45 structure consists of one extracellular domain, one transmembrane domain and two tandem intracellular catalytic domains. CD45 is a member of the protein tyrosine phosphatase (PTP) family, which regulates various cellular processes such as cell growth, differentiation, cell cycle, and oncogene transformation [3]. In addition, CD45 plays a key role in the activation of T cell and B cell antigen receptor-mediated dephosphorylation substrates, including p56lck, p59fyn, and other src family kinases[4].
Storage
PBS (pH7.4),0.05% Sodium Azide, 1% BSA, 40% Glycerol; at -20℃ for two years, avoid repeated freeze-thawing.
Shipping
Dry ice (-70℃)
[1] Charbonneau H, Tonks NK, Walsh KA, et al. The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase [J]. Proc Natl Acad Sci U S A. 1988, 85(19): 7182-6.
[2] Nakano A, Harada T, Morikawa S, et al. Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines [J]. Acta Pathol Jpn. 1990, 40(2): 107-15.
[3] Trowbridge IS, Johnson P, Ostergaard H, et al. Structure and function of CD45: a leukocyte-specific protein tyrosine phosphatase [J]. Adv Exp Med Biol. 1992, 323: 29-37.
[4] Penninger JM, Wallace VA, Kishihara K, et al. The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection [J]. Immunol Rev. 1993, 135: 183-214.
