ProteinFind® Anti-TSG101 Rabbit Monoclonal Antibody
Catalog Number： HE907-01
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Product Details
Tumor susceptibility gene 101 (TSG101) was discovered in 1996 and was located in the short arm of human chromosome 11 15.1-15.2[1]. Currently, TSG101 is considered to be a multifunctional domain protein containing three main functional regions: the first functional region is N-terminal domain containing Ubiquitin-conjugated (UBC) domain similar to the ubiquitin-ligase catalyzed domain; the second functional region has three independent DNA domains, namely transcription factor characteristic region, phage receptor domain similar region and proline rich region; and the third functional region is the stableiness box (SB) domain at the C-terminal. TSG101 is a dominant regulator of ubiquitination, which regulates ubiquitin-mediated protein degradation, affects cytokinesis, transcriptional regulation, cell cycle and proliferation, and viral release[2]. Studies have found that TSG101 is abnormally expressed in a variety of tumors. The expression of TSG101 in cervical cancer tissues is significantly lower than that in normal cervical tissues, and the expression in lung squamous cell carcinoma and lung adenocarcinoma tissues is lower than that in adjacent normal lung tissues [3,4].
Storage
PBS (pH7.4), 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol; at -20℃ for two years, avoid repeated freeze-thawing.
Shipping
Dry ice (-70℃)
[1] Li L, Li X, Francke U, et al. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer [J]. Cell, 1997, 88(1): 143-54.
[2] Hon KW, Ab-Mutalib NS, Abdullah NMA, et al. Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer [J]. Sci Rep, 2019, 9(1): 16497.
[3] Broniarczyk J, Olejnik-Schmidt AK, Luczak MW, et al. Analysis of expression and structure of the TSG101 gene in cervical cancer cells [J]. Int J Mol Med, 2010, 25(5): 777-83.
[4] Cai C, Zhang D, Lu P, et al. Expression and its significance of TSG101 in lung cancer tissue and lung cancer cell lines. [J]. Zhongguo Fei Ai Za Zhi, 2008, 11(2): 172-7.
