ProteinFind® Anti-CD81 Mouse Monoclonal Antibody
Catalog Number： HE906-01
Price：Please inquire first
Product Details
CD81, also known as TAPA-1, is a member of the transmembrane 4 protein superfamily (TM4SF). It is widely expressed in eukaryotic cell membranes, forms complexes with other quad-transmembrane proteins, integrins, co-receptors, MHC Class I and Class II molecules, and affects the adhesion, morphology, activation, proliferation and differentiation of B and T cells[1, 2]. In muscle, CD81 promotes cell fusion and muscle tube maintenance. CD81 is also a highly characterized hepatitis C virus receptor, which can promote the virus to invade target cells[3].
Storage
PBS (pH7.4), 0.02% Sodium Azide, 50% Glycerol; at -20℃ for two years, avoid repeated freeze-thawing.
Shipping
Dry ice (-70℃)
[1] Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system [J]. Annu Rev
Immunol. 1998, 16: 89-109.
[2] van Zelm MC, Smet J, Adams B, et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency [J]. J Clin
Invest. 2010, 120(4): 1265-74.
[3] Cherukuri A, Carter RH, Brooks S, et al. B Cell Signaling Is Regulated by Induced Palmitoylation of CD81 [J]. Journal of Biological Chemistry. 2004,
279(30): 31973-82.
[4] Sagi Y, Landrigan A, Levy R, et al. Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81
[J]. Proceedings of the National Academy of Sciences. 2012, 109(5): 1613-8.
[5] Charrin S, Latil M, Soave S, et al. Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81 [J]. Nat
Commun. 2013, 4: 1674.
[6] Bartosch B, Vitelli A, Granier C, et al. Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the
SR-B1 Scavenger Receptor [J]. Journal of Biological Chemistry. 2003, 278(43): 41624-30.
