Bax (Bcl-2-associated X protein) is a member of the Bcl-2 family. This protein can promote apoptosis in the form of a dimer with the Bcl-2 family.[1] When the cell is not stimulated by apoptotic signals, Bax is located in the cytoplasm. When cells are stimulated by apoptosis signals, such as staurosporine or DNA damage, Bax undergoes conformational changes to form heterodimers and then transfer from the cytoplasm to the outer mitochondrial membrane, opening the voltage-dependent anion channel (VDAC), changing the membrane potential, and releasing various pro-apoptotic factors, such as Cytochrome C, SMAC/Diablo, etc, which affect cell apoptosis.[2]
Storage
PBS (pH 7.4), 0.02% Sodium Azide, 50% Glycerol; at -20℃ for two years, avoid repeated freezing and thawing.
Shipping
Dry ice (-70℃)
[1]. Misao J, Hayakawa Y, Ohno M, Kato S, Fujiwara T, Fujiwara H. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction[J]. Circulation. 1996, 94 (7): 1506.
[2]. Valentijn AJ, Upton JP, Gilmore AP. Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization[J]. Biochemical Journal. 2008, 412 (2): 347-57.
Bio-Medicine
In Vitro Diagnostics
PCR, RT-PCR, qPCR, qRT-PCR
Restriction/Modifying Enzymes
DNA Molecular Weight Standards
Cloning and Mutagenesis System
Nucleic Acid Purification
Next Generation Sequencing
Gene Expression
Protein Analysis
Protein MW Standards
Cell Culture and Detection
Exosome Related
Serum-free medium
Antibodies
ELISA
Instruments
Residual DNA Detection
