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Stem Cell Related
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ProteinFind® Anti-Thy-1/CD90 Mouse Monoclonal Antibody


Product Details

Thy-1/CD90 is a GPI-anchored, developmentally regulated cell surface glycoprotein. It is involved in cell adhesion and cell communication of many cell types, especially in immune and nervous system cells. Thy-1/CD90 is widely used as a marker for hematopoietic stem cells [1]. Decreased expression of Thy1/CD90 mRNA and protein has been associated with the development of epithelial ovarian cancer, suggesting it may have a potential role of human ovarian cancer tumor suppressor genes [2]. Thy1/CD90 knockout mice have been shown to have impaired skin immune response and abnormal retinal development [3]. Thy1/CD90 is epigenetic regulated or dysregulated in some disease states such as pulmonary fibrosis, and the potentially reversible hypermethylation of the Thy1/CD90 promoter may provide new treatment options for this disease [4].


Storage

PBS (pH7.4), 0.02% Sodium Azide, 50% Glycerol; at -20℃ for two years, avoid repeated freeze-thawing.


Shipping

Dry ice (-70℃)

Citations

[1] Li Q, Wilkie AR, Weller M, et al. THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection [J]. PLoS Pathog, 2015, 11(7): e1004999.

[2] Abeysinghe HR, Cao Q, Xu J, et al. THY1 expression is associated with tumor suppression of human ovarian cancer [J]. Cancer Genet Cytogenet, 2003, 143(2): 125-32.

[3] Simon PD, Mcconnell J, Zurakowski D, et al. Thy-1 is critical for normal retinal development [J]. Brain Res Dev Brain Res,1999, 117(2): 219-23.

[4] Sanders YY, Pardo A, Selman M, et al. Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis [J]. Am J Respir Cell Mol Biol, 2008, 39(5): 610-8.

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