With the COVID-19 pandemic, fighting the epidemic has become the top priority of all tasks. As a biological reagent company, TransGen provides a series of related products to assist in the virus research.
On September 14th ,2020, Sai Li’s team from Tsinghua University and the team of Lanjuan Li from Zhejiang University jointly published a research paper entitled “Molecular architecture of the SARS-CoV-2 virus” online on Cell. This research allows us to further understand the SARS-CoV-2 virus, clarify its structure and assembly mechanism, and contribute to the research and defeat of the SARS-CoV-2 virus.
First, the researchers analyzed the molecular assembly of the authentic SARS-CoV-2 virus using cryo-electron tomography (cryo-ET) and subtomogram averaging (STA). Native structures of the S proteins in both pre- and postfusion conformations were determined to average resolutions of 8.7-11 Å. Compositions of the N-linked glycans from the native spikes were analyzed by mass-spectrometry, which revealed highly similar overall processing states of the native glycans to that of the recombinant glycoprotein glycans. Besides, the native conformation of the ribonucleoproteins (RNP) and its higher-order assemblies were revealed in this report. Overall, these characterization have revealed the architecture of the SARS-CoV-2 virus in exceptional detail, and shed lights on how the virus packs its ~30 kb long single-segmented RNA in the ~80 nm diameter lumen.
(structure of the SARS-CoV-2 virus)
The study needs endeavour of scientific researchers as well as support from high-quality products. With the advantages of high-efficiency DNA cloning, plasmid amplification, and stable quality, Trans10 Chemically Competent Cell and Transetta(DE3) Chemically Competent Cell from TransGen was selected by the team. It is an inspiration and recognition of TransGen to have the products listed on global top journals repeatedly. That represents the excellent quality and services of TransGen. TransGen sticks to the principle “Quality is the highest priority. To serve the scientific research with superior quality and service.” to provide everyone with high-quality and guaranteed products and services.
