CD81, also known as TAPA-1, is a member of the transmembrane 4 protein superfamily (TM4SF). It is widely expressed in eukaryotic cell membranes, forms complexes with other quad-transmembrane proteins, integrins, co-receptors, MHC Class I and Class II molecules, and affects the adhesion, morphology, activation, proliferation and differentiation of B and T cells [1, 2]. In muscle, CD81 promotes cell fusion and muscle tube maintenance. CD81 is also a highly characterized hepatitis C virus receptor, which can promote the virus to invade target cells [3].
Storage
PBS (pH7.4), 0.02% Sodium Azide, 50% Glycerol; at -20℃ for two years, avoid repeated freeze-thawing.
Shipping
Dry ice (-70℃)
[1] Cherukuri A, Carter RH, Brooks S, et al. B Cell Signaling Is Regulated by Induced Palmitoylation of CD81 [J]. Journal of Biological Chemistry, 2004, 279(30): 31973-82.
[2] Sagi Y, Landrigan A, Levy R, et al. Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81 [J]. Proceedings of the National Academy of Sciences, 2012, 109(5): 1613-8.
[3] Bartosch B, Vitelli A, Granier C, et al. Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the SR-B1 Scavenger Receptor [J]. Journal of Biological Chemistry, 2003, 278(43): 41624-30.
Bio-Medicine
In Vitro Diagnostics
PCR, RT-PCR, qPCR, qRT-PCR
Restriction/Modifying Enzymes
DNA Molecular Weight Standards
Cloning and Mutagenesis System
Nucleic Acid Purification
Next Generation Sequencing
Gene Expression
Protein Analysis
Protein MW Standards
Cell Culture and Detection
Exosome Related
Serum-free medium
Antibodies
ELISA
Instruments
Residual DNA Detection
