Anti-Human CD3 mAb (GMP Grade)
Catalog Number： HM101-01
Price：Please inquire first
Product Details
The CD3 molecule binds to the T-cell receptor (TCR) to form the CD3/TCR complex, which is involved in antigen recognition, signal transduction, and T cell activation[1]. CD3 monoclonal antibody specifically recognizes the CD3ε chain in the CD3/TCR complex, enabling T cell activation. It is the most widespread method for T cell activation and expansion in vitro that using co-stimulation with CD3 and CD28 monoclonal antibodies to mimic dual-signal T cell activation in vivo[2][3]. Mononuclear cells isolated from peripheral blood, bone marrow or umbilical cord blood can be cultured for a period of time in the presence of CD3 mAb, CD28 mAb and a variety of cytokines to obtain a large number of proliferating T cells. This product is produced by monoclonal cell lines, highly purified, and supplied in phosphate buffered saline (PBS, pH 7.4). It is xeno-free and can be used for CAR-T or TCR-T cell preparation.
Storage
at 2-8 ℃ for two years.
Shipping
ice bag (4℃)
1 Kuhns MS, Davis MM, Garcia KC: Deconstructing the Form and Function of the TCR/CD3 Complex. Immunity 2006, 24 (2):133-139.
2 Wang X, Rivière I: Clinical manufacturing of CAR T cells: foundation of a promising therapy. Molecular Therapy - Oncoly tics 2016, 3:16015.
3 Richards RM, Sotillo E, Majzner RG: CAR T Cell Therapy for Neuroblastoma. Frontiers in Immunology 2018, 9.
